Nick Bradbury: Feed Overload? Hit the Panic Button!: "The 'panic button' in this case is a feature I've added to the next pre-release of FeedDemon 2.6. FeedDemon will automatically detect when you've got a ton of unread items, and then offer to mark them (or a subset of them) as read."
Oh! Nice. I need several of those! I would be great if Google Reader trends would do that and even suggest feeds to drop.